Previous study points out that BJOE inhibits the proliferation of C6 glioma cells by suppressing the phosphoinositide 3-kinases (PI3K), protein Kinase B (AKT), and nuclear transcription factor-κB (NF-κB) protein expression, which also leads to inhibition of invasiveness of glioma cells, suggesting that the anti-tumor effect of BJOE relates to the inhibition of PI3K/AKT signal pathway [30]. Here, AKT1 is linked to central nervous system cancer.