For severe hypoglycemia, for which overview results were not statistically significant, Vardi and colleagues showed a reduction of 27% (OR 0.73; 95% CI 0.61; 0.87) and for nocturnal hypoglycemia, the results were in the same direction, with a significant reduction favouring insulin analogue (OR 0.70; 95% CI 0.63; 0.79) [30]. This evidence concerns the gene INS and Hypoglycemia.