ACE and Hypertension: It has been also showed that prenatal exposure to lipopolysaccharide (LPS), a nonspecific immune-inflammatory stimulant, led to hypertension in adult offspring rats, correlating with the augmentation of histone H3 acetylation (H3AC) on the angiotensin-converting enzyme 1 (ACE1) promoter, which induced the upregulation of the (ACE1) expression in renal cortex tissues [98,99,100].