In human cell lines, the luciferase activity of the ACE-1 promoter/reporter constructs of somatic ACE (sACE) was inhibited by DNA methylation and subsequent inhibition of DNA methylation and/or histone deacetylation by 5-aza-cytidine injections in rats restored sACE expression in the lung and liver, highlighting the epigenetic regulation of sACE in hypertension [9]. Here, ACE is linked to hypertensive disorder.