For example, a recent trans-ancestry genome-wide association study identified genetic variants at 12 new loci which have been differently DNA methylated in hypertension, four of these genes encoded proteins that participate in the regulation of vascular tone and VSMC plasticity, including: insulin like growth factor binding brotein 3 (IGFBP3), potassium two pore domain channel subfamily K member 3 (KCNK3), phosphodiesterase 3A (PDE3A), and PR domain-containing protein 6 (PRDM 6) [86]. This evidence concerns the gene PDE3A and hypertensive disorder.