PTEN and neoplasm: For instance, phosphatase and tensin homolog (PTEN), a well-characterized tumor-suppressor gene which acts as a master regulator of cell proliferation, is a target of miR-BART6-3p, as well as the BHRF1 cluster, while the latter can suppress the other known tumor suppressor, p27 (protein 27, also known as CDKN1B) [45,86,87].