CLL cells express four nucleoside transporters, namely hCNT2, hCNT3, hENT1, and hENT2, constitutively found at the mRNA level, whose protein expression is tightly modulated by different stimuli (e.g., phorbol 12-myristate 13-acetate, lipopolysaccharide, and tumor necrosis factor α), as well as nucleosides and nucleoside-derived drugs. Here, SLC29A2 is linked to B-cell chronic lymphocytic leukemia.