TNF and metabolic disease: 2000). Cytokines are directly linked to inflammation as they can exaggerate or reduce the inflammatory response through pro or anti-inflammatory cytokines, and in a metabolic disorder, there is an exacerbated formation of pro-inflammatory cytokines that can lead to damage to vital organs. The pro-inflammatory cytokines are interleukins (ILs) 1, 2, 6, 7, tumor necrosis factor (TNF) and interferon-γ (IFN-γ) (Kundu and Surh 2012).