Moreover, Franklin has reported that inflammatory monocytes are unable to differentiate into tumor associated macrophages in the absence of RBP-J by using CD11cCreRBP-Jf/f PyMT mice (Franklin et al., 2014), this result may also partly explain our findings why less macrophages were accumulated in fibrotic kidney in LyzCreRBP-Jf/f mice. The gene discussed is RBPJ; the disease is neoplasm.