Moreover, the depletion of CD11b+F4/80+CX3CR1+ resident renal macrophages exerted no obvious influence on UUO-induced renal fibrosis in either control or myeloid-specific RBP-J knockout mice, suggesting that myeloid-specific Notch signaling might not regulate renal fibrosis through kidney resident macrophages. The gene discussed is CX3CR1; the disease is renal fibrosis.