Meanwhile, upon CLs treatment, the infiltrated inflammatory cells and the degree of renal fibrosis in RBP-J cKO mice and control mice did not alter obviously compared with those after liposome treatment (PLs), as shown by H&E staining (Fig. 5C left panel and 5D) and Masson’s staining (Fig. 5C right panel and 5E). The gene discussed is RBPJ; the disease is renal fibrosis.