RBPJ and renal fibrosis: To determine the role of Notch signaling in macrophages during renal fibrosis, RBP-J-floxed mice were crossed with Lyz2-Cre transgenic mice to obtain macrophage-specific RBP-J knockout (Lyz2-Cre/RBP-Jf/f, RBP-J cKO) and control (Lyz2-Cre/RBP-J+/f, Ctrl) mice according to our previous study (He et al., 2015).