These results indicate that IL-6 treatment increases C/EBP-β binding to some extent while C/EBP-δ binding activity to a great extent in Alexander human hepatoma cells (Figs. 5A, 6B), demonstrating that the transcription factor C/EBP-δ is important in IL-6-induced inhibition of C/EBP promoter activity in Alexander human hepatoma cells. The gene discussed is CEBPD; the disease is hepatocellular carcinoma.