Numerous cancer vaccines have been developed but were fraught with failure in the recent past; such as CanvaxinTM for melanoma, MAGE-A3 for melanoma and lung cancer, OncoVAX® for colon cancer, Sipuleucel-T (Provenge®) for prostate cancer, and Oncolytic vaccines for glioblastomas. The gene discussed is MAGEA3; the disease is melanoma.