More efficient systems for the consistent expansion of TH1 type CD4+ T-cells needto be developed for clinical use and to further study: (1) for defining epitopes of tumor andviral antigens presented by class-II alleles that would enhance the effect of CD8+ T-cells (2)the functional activity and CD8+ cell help afforded by co-infusion of CD4 and CD8 T-cellsin-vivo (Table 2). This evidence concerns the gene CD4 and neoplasm.