TGFB1 and osteosarcoma: Of the THZ1 downregulated target super enhancer containing genes, many of them are critical oncogenes for osteosarcoma, for example, it has been reported that TGFB and CDK6 are important regulators of osteosarcoma proliferation and migration.26,27 Therefore, THZ1 inhibits osteosarcoma proliferation, migration, and invasion by targeting super enhancer containing oncogenic genes.