MYC and osteosarcoma: To study potential role of MYC in regulation of osteosarcoma, we first determined the association between MYC expression level and osteosarcoma patient prognosis using a published osteosarcoma patient transcriptome profiling dataset.14 We found that the expression of MYC is significantly up-regulated in the metastatic osteosarcoma patient samples compared to those non-metastasis samples, suggesting that MYC expression might promote the metastasis of osteosarcoma (Fig. 1a).