Concordantly, four additional datasets from the Oncomine database (Murat [21], Freije [22], Sun [23], and Phillips [24]) and two independent Portuguese and French glioma series, confirmed that HOTAIR expression is far more frequent in grades III and IV than in grade II gliomas and normal brain (Supplementary Table 1 and Supplementary Figure 1B). This evidence concerns the gene HOTAIR and central nervous system cancer.