IDH1 and central nervous system cancer: We further corroborated the relevance of these associations in IDH-wt GBM patients in the French dataset as the 3 intragenic methylation probes were also found to inversely correlate with HOTAIR expression (cg00079219 r = –0.53, p = 0.016; cg18824990 r = –0.523, p = 0.017; cg24895871 r = –0.521, p = 0.018), and in the combination of IDH-wt glioma grade III and IDH-wt GBM patients (cg00079219 r = -0.43, p = 0.004; cg18824990 r = –0.453, p = 0.002; cg24895871 r = −0.431, p = 0.004).