In 554 GBM patients from TCGA with available survival data, a statistically significant decrease in OS was observed in patients with high HOTAIR expression (n = 177, median OS = 383 days) as compared to patients whose GBMs presented low HOTAIR levels (n = 377, median OS = 447 days; p = 0.026 Log-rank test; Figure 4A). This evidence concerns the gene HOTAIR and glioblastoma.