ESR1 and breast carcinoma: However, when custom analysis was performed within this cohort (Cohort 2) for TNBC subset ER/PR/HER2 negative breast cancer patients (n = 309), a significant correlation was observed between high BAG3 mRNA expression and reduced overall survival, [p = 0.027, HR = 1.539, Cl (1.05–2.26)] (Figure 2B) and reduced recurrence free survival [p = 0.009, HR = 3.021, Cl (1.52–5.99)] (Figure 2C).