IGF2R and non-small cell lung carcinoma: We previously reported that GSE down-regulated the miR-17-92 cluster host gene (MIR17HG) and miR-19a/b in various NSCLC (A549, H520, H1299) and bronchial premalignant cancer cells, leading to up-regulations of their downstream targets - tumor suppressors PTEN and IGF2R [8].