POSTN and metastatic melanoma: Concerning metastatic melanoma, periostin (POSTN) was found to be expressed in the region surrounding melanoma cell nests in the metastatic melanoma lesions of wounded mice and humans [15], suggesting that it might stimulate TAMs to produce chemokines that induce melanoma-specific tumor-infiltrating lymphocytes (TILs) in melanoma patients with systemic inflammation.