As MYT1 transcription was shown to be induced by Ascl1, a transcription factor whose expression varies significantly between molecular subtypes of glioblastoma [41], we might speculate that this or other positive signals needed for MYT1 induction may be missing in our cell models, where thus H19 depletion and the consequent reduction of EZH2 binding to MYT1 promoter would not be sufficient to switch its transcription on. This evidence concerns the gene MYT1 and glioblastoma.