Even more directly related to our findings is the observation by Lin B. and colleagues [38] who, by studying H3K4me3 and H3K27me3 profiles in 8 glioblastoma stem cell lines, found that NKD1 promoter contains H3K27me3 marks in 5/8 GBM stem cell lines. The gene discussed is NKD1; the disease is glioblastoma.