We identified OR2A14, FER1L6, TAOK3, MAN1A2, MBNL2, SERBP1, PLEKHA2, SPTAN1, ADAMTS1, SLC30A5, ABCC1, SLC7A1 and SLC25A24 as candidate genes implicated in PC progression. This evidence concerns the gene TAOK3 and pachyonychia congenita.