Due to the monoallelic deletion of Beclin1, impaired autophagy results in reduced PALB2-associated breast tumorigenesis in the wild-type p53, but not in a conditionally null background, indicating that Beclin1-related autophagy plays a protumorigenic role in the wild-type p53 PALB2-associated breast cancer, but not in the p53 null tumors. This evidence concerns the gene TP53 and breast cancer.