SIRT3 and myocardial infarction: A study that is expected to be used in clinical trials showed that PLGA-PNIPAM microspheres loaded with the gastrointestinal nutrient NaB specifically binds to SIRT3 and activates its deacetylase function, thereby inhibiting ROS generation and autophagy, promoting angiogenesis and protecting cardiomyocytes in acute myocardial infarction (AMI) [142].