Oroxylin A (OA), which is derived from the root of Scutellaria baicalensis, was found to be a SIRT3 activator in an in vitro model of cardiac myocyte insulin resistance [120] and plays roles in preventing myocardial contractile function and improving myocardial fibrosis and heart failure [121]. Here, SIRT3 is linked to Myocardial fibrosis.