Biallelic changes of the tumor suppressor KEAP1 gene (by point mutations and loss of heterozygosity) were described for the first time in NSCLC [10] and, immediately after, in other several malignancies together with NFE2L2 mutations, the gene that codifies for the NRF2 protein [11]. The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.