IGF2 and acute myeloid leukemia: In addition, loss of imprinting (LOI) of IGF2/H19 mainly caused by “differentially methylated region” or “imprinting control region” (DMR/ICR) demethylation was shown as a frequent event in AML, adult T cell leukemia/lymphoma, and chronic myeloid leukemia (CML) [8–10].