AGER and type 2 diabetes mellitus: However, Kang et al. (2012) demonstrated that this variant of RAGE gene had no impact in T2DM pathogenesis and metabolic parameters to justify the hypothesis that -429T>C may be prone to cause diabetic micro-vascular complications.6 In view of current study -429T>C allelic frequencies were statistically non-significant between control and T2DM groups.