AGER and diabetes mellitus: The RAGE gene (chromosome 6; 6p21.3) is located near a histocompatibility complex.7 Promoter RAGE polymorphisms -429T>C (rs1800625) and 63 bp deletion (-345 to -407 bp) are associated with an increase in RAGE expression8 and diseases related with immune system such as systemic lupus erythematosus, Crohn's disease9 and DM.10