The RAGE gene (chromosome 6; 6p21.3) is located near a histocompatibility complex.7 Promoter RAGE polymorphisms -429T>C (rs1800625) and 63 bp deletion (-345 to -407 bp) are associated with an increase in RAGE expression8 and diseases related with immune system such as systemic lupus erythematosus, Crohn's disease9 and DM.10 This evidence concerns the gene AGER and systemic lupus erythematosus.