In addition to this list, a recent study has demonstrated that the myo-inositol oxygenase (MIOX; EC 1.13.99.1) enzyme has a significant role in AKI diagnosis.5 MIOX is the first and only enzyme of myo-inositol catabolism, which is the product of glucose intermediate metabolism, and is predominantly expressed in the kidney.6 Cystatin C is a protein produced by all nucleated cells, freely filtered from kidney glomeruli, and almost entirely reabsorbed in the tubules. This evidence concerns the gene CST3 and acute kidney injury.