Nearly all patients with cardiac disease at the acromegaly diagnosis die within 15 years.11 GH level, hypertension, and heart disease constitute the major indicators adversely affecting life expectancy in patients with acromegaly.12 In a recent Spanish study of 1,219 cases of acromegaly, 56 deaths occurred, and the most common cause was cardiovascular death.13 In patients with acromegaly, cardiovascular disease is expected to be higher due to hypertension (HT), glucose intolerance, and dyslipidaemia.14 This evidence concerns the gene GH1 and acromegaly.