Nevertheless, in a study using 3xTg-AD transgenic female mice that develop the complete AD neuropathology, the ovariectomized group that was treated with estrogens and progesterone showed a robust decrease in AT8 immunoreactivity, which detects tau phosphorylated at sites Ser/Thr202/205, in hippocampal neurons. The gene discussed is MAPT; the disease is Alzheimer disease.