The four miRNAs we focused on—miR-146a, miR-149, miR-196a2, and miR-499—are intimately related to regulation of TNF-α (El Gazzar et al., 2011), MTHFR (Wu et al., 2013), annexin A1 (ANXA1) (Luthra et al., 2008), and CRP (Yang et al., 2012) respectively, which were general causes of cerebral ischemia. The gene discussed is ANXA1; the disease is brain ischemia.