DKK1 and nervous system disorder: While the exact functions of Krm and Dkk1 in neural development remains unclear, recent observations show that both positive and negative modulation of Wnt/β-catenin signaling plays crucial role in developmental and physiological processes, including, tissue patterning, cancer cell-fate determination, and neurological disorders (Nakamura et al., 2008; Scott and Brann, 2013).