IRS2 and hydrops fetalis: On the other hand, intra-cerebroventricular (ICV) infusion of anti-miR-200a-3p to Lep°b/Lep°b mice restored the hypothalamic expression of Irs-2 and Lepr, and up-regulated the hypothalamic expression of Zfpm2, Insr, Pomc, and Npy. Pomc and miR-200a-3p expressions did not display any correlation or anti-correlation in groups C-C, C-HF, HF-C, and HF-HF of our study (R2 = 0.09).