In gliomas, cytosolic NADP+-dependent isocitrate dehydrogenase 1 (IDH1) became a more valuable determinant of disease characteristics, sensitivity to chemo/radiation therapy, and OS in glioma patients when compared with histological grades (Ichimura et al., 2009; Verhaak et al., 2010; Rohle et al., 2013). The gene discussed is IDH1; the disease is central nervous system cancer.