Thus far, few reports have been published on the association between IDH gene mutations and tumor immune cell infiltration, such as CD8+ T cells (Kohanbash et al., 2017), macrophages, and CD4+ T, B, and dendritic cells (Amankulor et al., 2017), as well as the connections between mutations and immune-checkpoint molecules (Berghoff et al., 2017; Hodges et al., 2017). The gene discussed is CD4; the disease is neoplasm.