In any case, persisting Notch1 signaling in T-ALL cells undergoing marked attenuation of Notch3 levels could partially rescue expression of Notch target genes following HDAC6 silencing in T-ALL cells, and shield these cells from the negative consequences of Notch signaling blockade, such as apoptosis or cell cycle arrest. Here, NOTCH1 is linked to acute lymphoblastic leukemia.