Plk2, for example, was among the genes that were further downregulated by MS in the context of mHTT. Activation of Plk2 has been shown in response to early insults such as prenatal stress and neonatal seizures suggesting a role in hippocampal synaptic downscaling and supporting the idea that Plk2 might be protective51. This evidence concerns the gene PLK2 and myeloid sarcoma.