Indeed, proteasome inhibitor has been proved to inhibit a range of cancer cell lines but much more potent against H460, another non-small cell lung cancer18, which might be related to the NF-κB-mediated antiapoptotic pathway in non-small cell lung cancer26 that decreased the level of Bcl-2 to directly associate with apoptosis27. Here, NFKB1 is linked to cancer.