PBMCs from 10 SLE patients and 8 HC were sorted into CD14+ monocytes, CD3+ T cells and CD56+CD3− NK cells, CD19+CD27−CD38− naïve B cells, CD19+CD27+CD38− memory B cells, and CD19+CD27+CD38+ plasmablasts. This evidence concerns the gene CD38 and systemic lupus erythematosus.