To that end, we performed immunohistochemistry staining on fibrotic Dupuytren’s tissue from human flexor tendons and observed ubiquitous levels of TGF-β1 and PAI-1 (Fig. 1), which is consistent with published reports implicating this pathway in mediating the fibrotic traits of Dupuytren’s disease in tendon23. Here, SERPINE1 is linked to Dupuytren Contracture.