ARHGEF10 and polyneuropathy: As we have learned recently in polyneuropathy-affected Leonbergers, where only approximately every third polyneuropathy-diagnosed Leonberger can be explained by the reported ARHGEF10 or GJA9 variants36,37, this case could possibly be explained by an independent mutation in an unknown gene causing polyneuropathy, although a possible effect of the NAPEPLD genotype could not be ruled out.