SRF and Alzheimer disease: Based on our analyses, we found that SRF-binding motifs were enriched in cells from various disease types, such as sigmoid colon for ulcerative colitis, T-helper cells for type 1 diabetes, hippocampus for Alzheimer’s disease, T-helper cells for multiple sclerosis, and atrial cardium for atrial fibrillation (Supplementary Fig. 14a).