We then assessed the impact of SIMV on the ability of MΦ to enhance infection of CD4+ T cells in trans compared to CD4+ T cell infection with cell-free virus in cis. Consistent with the data shown in Fig. 1D, untreated MΦ loaded with HIV-1 significantly enhanced infection in trans compared to CD4+ T cell in cis infection by day 12 (Fig. 7C). The gene discussed is CD4; the disease is infection.