TP53 and cancer: For example, PRDX3 is a mitochondrial protein with an antioxidant function which can negatively regulate apoptotic process, protect cells from oxidative stress, and promote cell survival in cancer (37); SEPW1 is a selenoprotein and an antioxidant involved in p53 signaling during cell apoptosis (38); STAT3 is in the STAT protein family, the members of which are key transcription activators involved in many cellular processes such as cell growth and apoptosis (39).