Whole-body or bone marrow cell–restricted knockout of OGG1 results in increased atherosclerosis in low-density lipoprotein receptor–null mice.8 However, OGG1 knockout results in massive 8oxoG accumulation, and the effects of endogenous levels of 8oxoG found in atherosclerosis and VSMC OGG1 are not known. This evidence concerns the gene VLDLR and atherosclerosis.