OGG1 and atherosclerosis: Thus, OGG1−/− mice allow examination of the effect of supraphysiological levels of 8oxoG in all tissues on atherosclerosis; SM22α-OGG1 mice allow determination of the effect of rescuing OGG1 activity and suppressing endogenous levels of 8oxoG in VSMCs only; and SM22α-OGG1K-R mice provide the acetylation-mutant control for SM22α-OGG1 mice.