This promoter is expressed in VSMCs in large arteries only26 and has an additional deletion of the CARG motif to prevent promoter downregulation during VSMC phenotypic change in atherosclerosis.27 SM22α-OGG1 and SM22α-OGG1K-R mice were compared against control mice and OGG1−/− mice.9 Mouse OGG1 mRNA expression was markedly reduced in all tissues in OGG1−/− mice but was not affected by coexpression of human OGG1 in SM22α-OGG1 or SM22α-OGG1K-R mice (Figure VIa in the online-only Data Supplement). The gene discussed is OGG1; the disease is atherosclerosis.