Among the correlations of gene expression levels with APOBEC-like motif counts and measures of kataegis, significant or nearly significant correlations were observed for UNG expression with kataegis measures (ρ between − 0.81 and − 0.80, 0.039 ≤ padj ≤ 0.063, n = 17, Ntests = 475) of the T(C>D)D motif in melanoma, and for APOBEC3A expression with motif counts and kataegis measures in renal cell carcinoma (ρ between 0.93 and 0.98, 0.008 ≤ padj ≤ 0.087 with n = 8 and Ntests = 510 for the T(C>D)R and T(C>D)D motifs; data not shown). The gene discussed is APOBEC3A; the disease is hereditary clear cell renal cell carcinoma.