For example, in pancreatic adenocarcinoma cell lines, log(IC50) values of tipifarnib, a farnesyl transferase inhibitor of the Ras pathway [90], the AKT kinase inhibitor VIII, and the IGF1R/insulin receptor inhibitor GSK-1904529A [36] were associated (|ρ| = 1, padj ≤ 5.15 × 10−22, n = 5, Ntests = 1834) with the overall counts of the motif T(C>K)W which is commonly attributed to APOBEC3B activity. This evidence concerns the gene INSR and pancreatic adenocarcinoma.