In contrast, APOBEC3B was reported to be less likely to play a role in mutagenesis of renal cell carcinoma cell lines [6, 12, 65], suggesting that high prevalence of mutation clusters in the RCC cell lines observed in our study could be generated by molecular factors other than APOBEC3B. The gene discussed is APOBEC3B; the disease is hereditary clear cell renal cell carcinoma.