The statistically significantly increased APOBEC3B gene and protein expression in hepatocellular carcinoma as compared to non-tumor tissues, as well as the high rates of C>D mutation changes in the genomes of hepatocellular carcinoma tumors have been documented previously [68–72], in agreement with an increased prevalence of APOBEC-like motifs in LIHC cell lines in our dataset (Fig. 3). The gene discussed is APOBEC3B; the disease is neoplasm.