In the pan-cancer analysis, APOBEC3B expression was significantly negatively correlated with sensitivity to an HSP90 (molecular chaperone heat shock protein 90) inhibitor 17-AAG (tanespimycin) (Table 6; ρ = − 0.293, padj = 5.85 × 10−9, n = 536, Ntests = 1375). The gene discussed is APOBEC3B; the disease is cancer.