DNER and pancreatic adenocarcinoma: In pancreatic adenocarcinoma (PAAD) cell lines, both APOBEC3A and UNG expression was significantly negatively correlated (Table 6; ρ ≤ − 0.819, padj ≤ 0.0001; n = 28 for APOBEC3A and 5 for UNG; Ntests = 26,610) with log(IC50) of the BET inhibitor JQ1 (Fig. 4a).