KRT16 and complex regional pain syndrome: Previous work using 2-d gels of hind paw skin homogenates probed with fracture and control mouse sera and further analyzed by liquid chromatography-mass spectroscopy demonstrated unique binding between fracture sera and fracture paw skin Krt16 protein, elevated expression of Krt16 in fracture paw skin, and increased mouse fracture sera and CRPS patient sera binding to recombinant Krt16 protein [25].