P2RX7 and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: The interest in P2RX7 as a therapeutic target in DMD results from the recent discovery that dystrophinopathy causes functional alterations of this purinoceptor and that the genetic ablation and pharmacological inhibition of P2RX7 in mdx mice produced significant improvements in key functional and molecular disease parameters [24, 58, 74].