Among 17 cases, the response was evaluated in the 3 patients with ALK-positive advanced NSCLC who received crizotinib therapy; 2 patients were failed by NGS (case 3: PFS, 7.4 months and OS, 22.5 months; case 17: PFS, 1.0 month and OS, 8.4 months), 1 patient was successfully evaluated by NGS (case 12: FBXO36-ALK PFS, 21.2 months and OS, > 46.7 months). This evidence concerns the gene ALK and non-small cell lung carcinoma.