In particular, KRAS mutation has been reported as a representative factor indicative of poor prognosis in ICC [12–14], and our patients with mutated KRAS showed significantly worse survival compared to those with wild-type KRAS. Regarding glucose metabolism, Warburg discovered that, even in the presence of oxygen, cancer cells undergo aerobic glycolysis rather than the normal oxidative phosphorylation. Here, KRAS is linked to cancer.