Results from our study thus suggest the presence of heightened excitatory signal (glutamate) and decreased inhibitory currents (serotonin, dopamine, GABA and acetylcholine), which may be responsible for the increased pulsatility of GnRH and LH, leading to increased LH/FSH ratio as observed in PCOS (Fig. 7). The gene discussed is GNRH1; the disease is polycystic ovary syndrome.