Further, there was a significant increase in the body weight (Fig. 1f) (P < 0.01), glucose intolerance (Fig. 1g), area under the curve for glucose (Fig. 1h), serum insulin level (P < .001) and HOMA-IR index (Table 2) of letrozole treated group as compared to the CMC control group. This evidence concerns the gene INS and Glucose intolerance.