The malaria severity signature contains six genes that were associated with severe malaria, including carbonic anhydrase 1 (CA1), G-protein-coupled receptor 89B (GPR89B), lipocalin 2 (LCN2), thymidine kinase 1 (TK1), small nucleolar RNA, C/D box 30 (SNORD30), and TBC1 domain family member 3 (TBC1D3) (P ≤ 0.05; fold change of ≥ 1.5) [31]. The gene discussed is GPHRB; the disease is malaria.