Further analysis of the correlation between mRNA expression levels of these genes and prognosis revealed that 14 of them, including VIM, EPHX3, ACVR1, ANGPT1, TPM3, ALOX15, DIO1, KCNJ2, RSPH9, SOSTDC1, SYCP2, MACF1, TDRD5 and CELSR3, were significantly related to breast cancer prognosis (Table 1). The gene discussed is RSPH9; the disease is breast cancer.