AKT1 and melanoma: Because resistance to cisplatin treatment is one of major causes for chemotherapy failure in treating melanoma [18–20], the discovery of miR-30a-5p as a contributing factor of cisplatin resistance and the identification of the regulatory miR-30a-5p/IGF1R/AKT/P53 signaling axis would help design strategies to increase the efficacy of chemotherapeutic treatment of melanoma.