Finally, after its induced synthesis following viral infection, poly(RC) binding protein 2 (PCBP2) negatively regulates the RIG-I/MAVS signaling pathway by interacting with MAVS and recruiting E3 ligase atrophin-1-interacting protein 4 (AIP4) for MAVS degradation by the proteasome [201]. Here, MAVS is linked to viral infectious disease.