Regarding the ability of tumor cells to affect osteoblast differentiation and activity, it was shown that exosomes isolated from MDA PCa 2b cells (a PCa bone metastasis cell line) contain miR-141-3p and can transfer their content into osteoblasts; miR-141-3p reduced the protein levels of its target gene DLC1 and activated p38 MAPK signaling, which increased the expression of OPG and further promoted osteoblast activity [71]. This evidence concerns the gene DLC1 and posterior cortical atrophy.